Cardiovascular Precision Medicine Clinic

Introduction

What is Cardiovascular Precision Medicine?

Cardiovascular Precision Medicine is a clinical pathway that takes advantage of genetic or genomic, epigenetic and metabolomic (‘omic’) information to optimise your care and healthcare journey at the CUHK Medical Centre. Technological advances have enabled evaluation and treatment that is custom-tailored to one’s genetic make-up and life exposures. We will also take care of your family and provide appropriate screening and diagnostic tests, as well as current evidence-based investigations and treatments.

What genetics standards are followed?

We adopt internationally accredited genetics tests, and our clinical practices follow the American and European guidelines. We tailor our care and testing to meet ethnic differences and needs.

What members make up the Cardiovascular Precision Medicine team?

The team consists of cardiologists, clinical geneticists, genetic counsellors, and a multidisciplinary team. They will provide appropriate consultations based on your condition. If your condition requires intervention procedures, we will refer you to the appropriate specialist(s) for further follow-up.

Our Services

Service that we offer

Cardiovascular Precision Medicine offers a comprehensive service beyond genetic or genomic testing. Includes a detailed cardiology assessment, imaging (e.g. echocardiography, Computed Tomography (CT) angiography, Magnetic Resonance Imaging (MRI), nuclear scan), exercise physiology and stress testing (e.g. treadmill, cycle ergometry), and invasive tests if needed.

As information from genetic or genomic assessment is complex and changes over time, it is common to often consult with a clinical geneticist both before and after undergoing the test(s). Genetic counselling will help patients or families with a genetic disease to understand the need, limitation and benefits of testing, as well as the nature, mode and nature of inheritance of the disease, risk and frequency of occurrence within the family, and the means of prevention to make informed decisions in family plans. The cardiologist may perform other examinations to evaluate a condition, arrange tests to confirm a diagnosis as to develop the best treatment plan for you.

Target Group
Inherited cardiovascular diseases Arrhythmias and channelopathies include Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia (CPVT), short QT syndrome (SQTS) and long QT syndrome (LQTS) Cardiomyopathy (CMP) including arrhythmogenic right ventricular cardiomyopathy (ARVC), dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM) and left ventricular non-compaction cardiomyopathy (LVNC) Congenital structural heart disease Connective tissue disorder including Ehlers-Danlos syndrome, Loeys-Dietz syndrome and Marfan syndrome Hereditary haemorrhagic telangiectasia Heterotaxy and situs inversus Liddle syndrome Noonan syndrome Pulmonary artery hypertension (PAH) Inherited conditions that increase the risk of heart disease Familial hypercholesterolaemia Hereditary haemochromatosis Amyloidosis Related family medical history Sudden cardiac death

Target Group

Inherited cardiovascular diseases

Arrhythmias and channelopathies include Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia (CPVT), short QT syndrome (SQTS) and long QT syndrome (LQTS)
Cardiomyopathy (CMP) including arrhythmogenic right ventricular cardiomyopathy (ARVC), dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM) and left ventricular non-compaction cardiomyopathy (LVNC)
Congenital structural heart disease
Connective tissue disorder including Ehlers-Danlos syndrome, Loeys-Dietz syndrome and Marfan syndrome
Hereditary haemorrhagic telangiectasia
Heterotaxy and situs inversus
Liddle syndrome
Noonan syndrome
Pulmonary artery hypertension (PAH)

Inherited conditions that increase the risk of heart disease

Familial hypercholesterolaemia
Hereditary haemochromatosis
Amyloidosis

Related family medical history

Sudden cardiac death

Genetic Testing

Genetic testing usually collects a small sample of blood or tissue from the client. DNA (genes) contained in the sample cells can be tested to detect variation or mutation that are at risk of developing any genetic condition. Depending on the type of genetic test performed, the availability of genetic result takes weeks.

Test
Disease-focused Gene Panels Aortic disease (aortopathy) Arrhythmia Arrhythmogenic right ventricular cardiomyopathy (ARVC) Atrial fibrillation (AF) Brugada syndrome Cardiomyopathy (CMP) Catecholaminergic polymorphic ventricular tachycardia (CPVT) Congenital structural heart disease Dilated cardiomyopathy (DCM) Dyslipidaemia including familial hyperlipidaemia Ehlers-Danlos syndrome Hereditary haemorrhagic telangiectasia Heterotaxy and situs inversus Hypertrophic cardiomyopathy (HCM) Left ventricular non-compaction cardiomyopathy (LVNC) Liddle syndrome Loeys-Dietz syndrome Long QT syndrome (LQTS) Marfan syndrome Noonan syndrome Pulmonary artery hypertension (PAH) Short QT syndrome (SQTS) Whole Exome Sequencing (WES) Whole Genome Sequencing (WGS)

Test

Disease-focused Gene Panels